食品生理学研究室

＊アンダーラインは研究室関係者

■　原著（Original papers: 23）

1. Arakawa S, Inoue M, Kinouchi R, Morizumi S, Yamaguchi M, ShimazuY, Takeda M. Dietary constituents genistein inhibits the hyperexcitability of trigeminal nociceptive neurons associated with mechanical hyperalgesia following orofacial inflammation. J Oral Biosci (in press)
2. Shimazu Y, Kobayashi, Endo S, Takemura J, Takeda M. Dietary constituent, lutein inhibits acute inflammation-induced c-fos expression of rat trigeminal spinal nucleus caudalis and C1 dorsal horn neurons. Eur J Oral Sci (in press)
3. Shinoda M, Fukuoka T, Takeda M, Noguchi K, Iwata K. (2019). Spinal glial cell line-derived neurotrophic factor infusion reverses reduction of Kv4.1-mediated A-type potassium currents of injured myelinated primary afferent neurons in a neuropathic pain model. Mol Pain 15:174480691984119
4. Hidaka S, Kanai Y, Takehana S, Syoji Y, Kubota Y, Uotsu N, Yui K, Shimazu Y Takeda M.（2019） Systemic administration of α-lipoic acid suppresses excitability of nociceptive wide-dynamic range neurons in rat spinal trigeminal nucleus caudalis Neurosci Res 144,14-20
5. Syoji Y, Kobayashi R, Miyamura N, Hirohara T, Kubota Y, Uotsu N, Yui K, Shimmazu Y, Takeda M. (2018) Suppression of hyperexcitability of trigeminal nociceptive neurons associated with inflammatory hyperalgesia following systemic administration lutein via inhibition of cyclooxygenase-2 cascade signaling. J Inflamm 15:24
6. Nakajima R, Uehara A, Takehana S, Akama Y, Shimazu Y and Takeda M (2018) Decanoic acid attenuates the excitability of nociceptive trigeminal primary and secondary neuron associated with hypoalgesia.J Pain Res 11:2867-2876
7. Nakazaki S, Tadokoro K, Takehana S, Syoji S, Shimazu Y, Takeda M (2018) Docosahexaenoic acid attenuates inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis neurons associated with hyperalgesia in rats. Eur J Oral Sci 126: 458-465
8. Mitome K, Takehana S, Oshima K, Shimazu Y, Takeda M (2018) local anesthetic effect of docosahexaenoic acid on the nociceptive jaw-opening reflex in rats. Neurosci Res 137:30-35
9. Kakita K, Tsubouchi H, Adachi M, Takehana S, Shimazu Y, Takeda M (2018)　Local subcutaneous injection of chlorogenic acid inhibits the nociceptive trigeminal spinal nucleus caudalis neurons in rats. Neurosci Res 134:49-55
10. Takeda M, Nasu M, Kanazawa T, Takahashi M, Shimazu Y (2017) Chemokine ligand 2 / chemokine receptor 2 signaling in the trigeminal ganglia contributes to inflammatory hyperalgesia in rats. Neurosci Res 128:25-32.
11. Matsumoto Y, Komatsu K, Takehana S, Syoji Y, Kobayashi A, Shimazu Y, Takeda M (2017) Effect of resveratrol on c-fos expression of rat trigeminal spinal nucleus caudalis and C1 dorsal horn neurons following mustard oil-induced acute inflammation Eur J Oral Sci 125:338-344.
12. Noguchi Y, Matsuzawa N, Akama Y, Sekiguchi K, Takehana S, Shimazu Y, Takeda M (2017) Dietary constituents, decanoic acid suppresses the excitability of nociceptive trigeminal neuronal activity associated with hypoalgesia via muscarinic M₂ receptor signaling. Mol Pain, 13:1744806917710779
13. Kokuba S, Takehana S, Oshima K, Shimazu Y, Takeda M (2017) Systemic administration of the dietary constituent resveratrol inhibits the nociceptive ja-opening reflex in rats via the endogenous opioid system. Neurosci Res 119:1-6
14. Kubo A, Shinoda M, Katagiri A, Takeda M, Suzuki T, Asaka J, Yeomans DC, Iwata K (2017) Oxytocin alleviates orofacial mechanical hypersensitivity associated with infraorbital nerve injury through vasopressin-1A receptors of the rat trigeminal ganglia. Pain 158:649-659.
15. Takehana S, Kubota Y, Uotsu N, Yui K, Shimazu Y, Takeda M (2017) Acute intravenous administration of dietary constituent theanine suppress noxious neuronal synaptic transmission of trigeminal spinal nucleus caudalis in rats. Brain Res Bull 131:70-77.
16. Takehana S, Kubota Y, Uotsu N, Yui K, Iwata K, Shimazu Y, Takeda M (2017) The dietary constituent resveratrol suppresses nociceptive transmission via NMDA receptor. Mol Pain 13:1744806917697010
17. Shimazu Y, Shibuya E, Takehana S, Sekiguchi K, Oshima K, Kamata H, Karibe H, Takeda M (2016) Local administration of resveratrol inhibits excitability of nociceptive wide-dynamic range neurons in rat trigeminal spinal nucleus caudalis. Brain Res Bull 124:262-268.
18. Takehana S, Sekiguchi K, Inoue M, Kubota Y, Ito Y, Yui K, Shimazu Y, Takeda M (2016) Systemic administration of resveratrol suppress the nociceptive neuronal activity of spinal trigeminal nucleus caudalis in rats. Brain Res Bull 120:117-122.
19. Sekiguchi K, Takehana S, Shibuya E, Matsuzawa N, Hidaka H, Kanai Y, Inoue M, Kubota Y, Shimazu Y, Takeda M (2016) Resveratrol attenuates inflammation-induced hyperexcitability of trigeminal spinal nucleus caudalis neurons associated with hyperalgesia in rats. Mol Pain 12:1744806916643082
20. Takeda M, Nasu M, Kanazawa T, Shimazu Y (2015) Activation of GABA_B receptor potentiates inward rectified potassium current of satellite glial cells from trigeminal ganglia in rats. Neuroscience 288:51-58.
21. Shinoda M, Takeda M, Honda K, Maruno M, Katagiri A, Satoh-Kuriwada S, Shoji N, Tsuchiya M, Iwata K (2015) Involvement of peripheral artemin signaling in tongue pain: possible mechanism in burning mouth syndrome. Pain 156:2528-37.
22. Takeda M, Takahashi M, Matsumoto S (2014) Inflammation enhanced brain derived neurotrophic factor-induced suppression of the voltage-gated potassium currents in small-diameter trigeminal ganglion neurons projecting to the trigeminal nucleus interpolaris/caudalis transition zone. Neuroscience 261: 223-231.
23. Takahashi M, Takeda M, Matstumoto S (2014) Somatostatin enhances tooth-pulp-evoked cervical dorsal horn neuronal activity in the rat via inhibition of GABAergic interneuron. Brain Res Bull 100:76-83.

■　総説（Review: 4）

1. Takeda M and Shimazu Y. Modulatory mechanism underlying how dietary constituents attenuate orofacial pain. J Oral Sci (in press)
2. 武田 守, 竹鼻 志織, 島津 徳人:食品成分による疼痛緩和：レスベラトロール、運動器疼痛学会誌 9:192-197, 2017
3. Goto T, Oh SB, Takeda M, Shinoda M, Sato T, Gunjikake KK, Iwata K (2016) Recent advances in basic research on the trigeminal ganglion. J Physiol Sci 66:381-6.
4. Takeda M, Takehana S, Sekiguchi K, Kubota Y and Shimazu Y (2016) Modulatory mechanism of nociceptive neuronal activity by dietary constituents resveratrol. Int J Mol Sci 17:1702.

■　著書（Book: 2）

1. Iwata K, Takeda M, Oh S, Shinoda M: "Neurophysiology of Orofacial Pain" Contemporary Oral Medichine, C.S. Farah et al. (Eds.) Springer International Publishing, 2017
2. Takeda M, Takehana S, Shimazu Y, The polyphenolic Compound Resveratrol attenuates Pain :Neurophysiological mechanisms. Polyphenol: mechniasms of action in Human Health and Disease, Academic Press, 2^nd Ed., pp 237-247. Eds. Ronald Watson Victor Preedy Sherma Zibadi, Academic Press, 2018.