基礎教育研究室・化学

Basic Education - Chemistry

業績目録

投稿日:2017年03月09日

原著

  1. Kanno K, Tsurukawa Y, Kamisuki S,* Shibasaki H, Iguchi K, Murakami H, Uchiyama J, Kuramochi K. (Corresponding author)
    Novel neuroprotective hydroquinones with a vinyl alkyne from the fungus, Pestalotiopsis microspora. (査読付)
    J. Antibiot. in press

  2. Takeuchi T, Sriwilaijaroen N, Sakuraba A, Hayashi E, Kamisuki S, Suzuki Y, Ohrui H, Sugawara F.
    Design, Synthesis, and Biological Evaluation of EdAP, a 4'-Ethynyl-2'-Deoxyadenosine 5'-Monophosphate Analog, as a Potent Influenza a Inhibitor. (査読付)
    Molecules 24(14), E2603 (2019)

  3. Tanaka N, Nakajima M, Narukawa-Nara M, Matsunaga H, Kamisuki S, Aramasa H, Takahashi Y, Sugimoto N, Abe K, Terada T, Miyanaga A, Yamashita T, Sugawara F, Kamakura T, Komba S, Nakai H, Taguchi H.
    Identification, characterization and structural analyses of a fungal endo-β-1,2-glucanase reveal a new glycoside hydrolase family. (査読付)
    J. Biol. Chem. 294(19), 7942-7965 (2019)
  4. Ruike, T., Kanai, Y., Iwabata, K., Matsumoto, Y., Murata, H., Ishima, M., Ohta, K., Oshige, M., Katsura, S., Kuramochi, K., Kamisuki, S., Sahara, H., Miura, M., Sugawara, F., Sakaguchi, K.
    Distribution and metabolism of 14C-Sulfoquinovosylacylpropanediol (14C-SQAP) after a single intravenous administration in tumor-bearing mice. (査読付)
    Xenobiotica 49(3), 346-362 (2019)

  5. Ohashi H, Nishioka K, Nakajima S, Kim S, Suzuki R, Aizaki H, Fukasawa M, Kamisuki S, Sugawara F, Ohtani N, Muramatsu M, Wakita T, Watashi K.
    The aryl hydrocarbon receptor-cytochrome P450 1A1 pathway controls lipid accumulation and enhances the permissiveness for hepatitis C virus assembly.(査読付)
    J. Biol. Chem. 293(51), 19559-19571 (2018)

  6. Kamisuki, S.,* Himeno, N., Tsurukawa, Y., Kusayanagi, T., Takeno, M., Kamakura, T., Kuramochi, K., Sugawara, F. (Corresponding author)
    Identification of proteins that bind to the neuroprotective agent neoechinulin A. (査読付)
    Biosci. Biotechnol. Biochem. 82(3), 442-448. (2018)

  7. Kanda, Y., Yamasaki, Y., Sasaki-Yamaguchi, Y., Ida-Koga, N., Kamisuki, S., Sugawara, F., Nagumo, Y., Usui, T.
    TRPA1-dependent reversible opening of tight junction by natural compounds with an α,β-unsaturated moiety and capsaicin. (査読付)
    Sci. Rep. 8(1), 2251 (2018)
  8. Abe, K., Nakajima, M., Yamashita, T., Matsunaga, H., Kamisuki, S., Nihira, T., Takahashi, Y., Sugimoto, N., Miyanaga, A., Nakai, H., Arakawa, T., Fushinobu, S., Taguchi, H.
    Biochemical and structural analyses of a bacterial endo-β-1,2-glucanase reveal a new glycoside hydrolase family. (査読付)
    J. Biol. Chem. 292(18), 7487-7506 (2017)
  9. Kanda, Y., Yamasaki, Y., Shimura, S., Kamisuki, S., Sugawara, F., Nagumo, Y., Usui, T.
    MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane. (査読付)
    J. Antibiot. 70(5), 691-694 (2017)
  10. Sasaki-Hamada, S., Hoshi, M., Niwa, Y., Ueda, Y., Kokaji, A., Kamisuki, S., Kuramochi, K., Sugawara, F., Oka, J.
    Neoechinulin A induced memory improvements and antidepressant-like effects in mice. (査読付)
    Prog. Neuropsychopharmacol. Biol. Psychiatry 71, 155-161 (2016)

  11. Nakajima, S., Watashi, K., Ohashi, H., Kamisuki, S., Izaguirre-Carbonell, J., Kwon, A.T., Suzuki, H., Kataoka, M., Tsukuda, S., Okada, M., Moi, M.L., Takeuchi, T., Arita, M., Suzuki, R., Aizaki, H., Kato, T., Suzuki, T., Hasegawa, H., Takasaki, T., Sugawara, F., Wakita, T.
    Fungus-Derived Neoechinulin B as a Novel Antagonist of Liver X Receptor, Identified by Chemical Genetics Using a Hepatitis C Virus Cell Culture System. (査読付)
    J. Virol. 90(20), 9058-9074 (2016)

  12. Nakajima, Y., Iguchi, H., Kamisuki, S., Sugawara, F., Furuichi, T., Shinoda,Y.
    Low doses of the mycotoxin citrinin protect cortical neurons against glutamate-induced excitotoxicity. (査読付)
    J. Toxicol. Sci. 41(2), 311-319 (2016)
  13. Nishikori, S.,# Takemoto, K.,# Kamisuki, S.,# Nakajima, S., Kuramochi, K., Tsukuda, S., Iwamoto, M., Katayama, Y., Suzuki, T., Kobayashi, S., Watashi, K., Sugawara, F. (#equal contribution)
    Anti-hepatitis C virus natural product from a fungus Penicillium herquei. (査読付)
    J. Nat.Prod. 79(2), 442-446 (2016)
  14. Izaguirre Carbonell , J., Kawakubo, H., Murata, H., Tanabe, A., Takeuchi, T., Kusayanagi, Tomoe., Tsukuda, S., Hirakawa, T., Iwabata, K., Kanai, Y., Ohta, K., Miura, M., Sakaguchi, K., Matsunaga, S., Sahara, H., Kamisuki, S.,* Sugawara, F.* (Corresponding author)
    Novel anticancer agent, SQAP, binds to focal adhesion kinase and modulate its activity.(査読付)
    Sci. Rep. 5, 15136 (2015)
  15. Kaneko, M., Watashi, K., Kamisuki, S., Matsunaga, H., Iwamoto, M., Kawai, F., Ohashi, H., Tsukuda, S., Shimura, S., Suzuki, R., Aizaki, H., Sugiyama, M., Park, S.Y., Ito, T., Ohtani, N., Sugawara, F., Tanaka, Y., Mizokami, M., Sureau, C., Wakita, T.
    A novel tricyclic polyketide, vanitaracin A, specifically inhibits the entry of hepatitis B and D viruses through targeting NTCP.(査読付)
    J. Virol. 89(23), 11945-11953 (2015).
  16. Ikeda, K.,# Kamisuki, S.,# Uetake, S., Mizusawa, A., Ota, N., Sasaki, T., Tsukuda, S., Kusayanagi, T., Takakusagi, Y., Morohashi, K., Yamori, T., Dan, S., Shiina, I., Sugawara, F. (#equal contribution)
    Ridaifen G, tamoxifen analog, is a potent anticancer drug working through a combinatorial association with multiple cellular factors. (査読付)
    Bioorg Med Chem. 23(18):6118-6124 (2015)
  17. Matsunaga, H.,# Kamisuki, S.,# Kaneko, M., Yamaguchi, Y., Takeuchi, T., Watashi, K., Sugawara, F. (#equal contribution)
    Isolation and structure of vanitaracin A, a novel anti-hepatitis B virus compound from Talaromyces sp. (査読付)
    Bioorg. Med. Chem. Lett. 25(19), 4325-4328 (2015)
  18. Shishido, T., Hachisuka, M., Ryuzaki, K., Miura, Y., Tanabe, A., Tamura, Y., Kusayanagi, T., Takeuchi, T., Kamisuki, S., Sugawara, F., Sahara, H.
    EpsinR, a target for pyrenocine B, role in endogenous MHC-II-restricted antigen presentation.(査読付)
    Eur. J. Immunol. 44(11), 3220-3231 (2014)
  19. Takemoto, T., Kamisuki, S.,* Chia, P., Kuriyama, I., Mizushina, Y., Sugawara, F. (Corresponding author)
    Bioactive dihydronaphthoquinone derivatives from Fusarium solani.(査読付)
    J. Nat. Prod., 77(9), 1992-1996 (2014)
  20. Mizushina, Y., Ogawa, Y., Onodera, Y., Kuriyama, I., Sakamoto, Y., Nishikori, S., Kamisuki, S., Sugawara, F.
    Inhibition of mammalian DNA polymerases and the suppression of inflammatory and allergic responses by tyrosol from used activated charcoal waste generated during sake production. (査読付)
    J. Agric. Food Chem., 62(31), 7779-7786 (2014)
  21. Myobatake, Y., Takemoto, K., Kamisuki, S., Inoue, N., Takasaki, A., Takeuchi, T., Mizushina, Y., Sugawara, F.
    Cytotoxic alkylated hydroquinone, phenol and cyclohexenone derivatives from Aspergillus violaceofuscus Gasperini. (査読付)
    J. Nat. Prod., 77(5), 1236-1240 (2014)
  22. Mizushina Y., Suzuki-Fukudome, H., Takeuchi, T., Takemoto, K, Kuriyama, I., Yoshida, H., Kamisuki, S., Sugawara, F.
    Formosusin A, a novel specific inhibitor of mammalian DNA polymerase β from the fungus Paecilomyces formosus. (査読付)
    Bioorg. Med. Chem., 22(3), 1070-1076 (2014)
  23. Shimura, S., Ishima, M., Nakajima, S., Fujii, T., Himeno, N., Ikeda, K., Izaguirre-Carbonell, J., Murata, H., Takeuchi, T., Kamisuki, S., Suzuki, T., Kuramochi, K., Watashi, K., Kobayashi, S., Sugawara, F.
    Total synthesis and anti-hepatitis C virus activity of MA026. (査読付)
    J. Am. Chem. Soc., 135(50), 18949-18956 (2013)
  24. Nakajima, S., Watashi, K., Kamisuki, S., Tsukuda, S., Takemoto, K., Matsuda, M., Suzuki, R., Aizaki, H., Sugawara, F., Wakita, T.
    Specific inhibition of hepatitis C virus entry into host hepatocytes by fungi-derived sulochrin and its derivatives. (査読付)
    Biochem. Biophys. Res. Commun., 440(4), 515-520 (2013)
  25. Kuramochi, K., Tsubaki, K., Kuriyama, I., Mizushina, Y., Yoshida, H., Takeuchi, T., Kamisuki, S., Sugawara, F., Kobayashi, S.
    Synthesis, structure, and cytotoxicity studies of some fungal isochromanes. (査読付)
    J. Nat. Prod., 76(9), 1737-1745 (2013)
  26. Tsukuda, S., Kusayanagi, T., Umeda, E., Watanabe, C., Tosaki, Y., Kamisuki, S., Takeuchi, T., Takakusagi, Y., Shiina, I., Sugawara, F.
    Ridaifen B, a tamoxifen derivative, directly binds to Grb10 interacting GYF protein 2. (査読付)
    Bioorg. Med. Chem., 21(1), 311-320 (2013)
  27. Kusayanagi, T., Tsukuda, S., Shimura, S., Manita, D., Iwakiri, K., Kamisuki, S., Takakusagi, T., Takeuchi, T., Kuramochi, K., Nakazaki, A., Sakaguchi, K., Kobayashi, S., Sugawara, F.
    The antitumor agent doxorubicin binds to Fanconi anemia group F protein. (査読付)
    Bioorg. Med. Chem., 20(21), 6248-6255 (2012)
  28. Takeuchi, T., Mizushina, Y., Takaichi, S., Inoue, N., Kuramochi, K., Shimura, S., Myobatake, Y., Katayama, Y., Takemoto, K., Endo, S., Kamisuki, S., Sugawara, F.
    Total synthesis of (+)-Sch 725680: inhibitor of mammalian A-, B-, and Y-family DNA polymerases. (査読付)
    Org. Lett., 14(17), 4303-4305 (2012)
  29. Miyano, Y., Tsukuda, S., Sakimoto, I, Takeuchi, R, Shimura, S., Takahashi, N., Kusayanagi, T., Takakusagi, T., Okado, M., Matsumoto, Y., Takakusagi, K., Takeuchi, T., Kamisuki, S., Nakazaki, A., Ohta, K., Miura, M., Kuramochi, K., Mizushina, Y., Kobayashi, S., Sugawara, F., Sakaguchi, K.
    Exploration of the binding proteins of perfluorooctane sulfonate by a T7 phage display screen. (査読付)
    Bioorg. Med. Chem., 20(13), 3985-3990 (2012)
  30. Manita, D., Toba, Y., Takakusagi, Y., Matsumoto, Y., Kusayanagi, T., Takakusagi, K., Tsukuda, S., Takada, K., Kanai, Y., Kamisuki, S., Sakaguchi, K., Sugawara, F.
    Camptothecin (CPT) directly binds to human heterogeneous nuclear ribonucleoprotein A1 (hnRNP A1) and inhibits the hnRNP A1/ topoisomerase I interaction. (査読付)
    Bioorg. Med. Chem., 19(24), 7690-7697 (2011)
  31. Egami, H., Kamisuki, S., Dodo, K., Asanuma, M., Hamashima, Y., Sodeoka, M.
    Catch and release of alkyne-tagged molecules in water by a polymer-supported cobalt complex. (査読付)
    Org. Biomol. Chem., 9(22), 7667-7670 (2011)
  32. Kamisuki, S., Shirakawa, T., Kugimiya, A., Abu-Elheiga, L., Choo, H.P., Yamada, K., Shimogawa, H., Wakil, S. J., Uesugi, M.
    Synthesis and Evaluation of Diarylthiazole Derivatives That Inhibit Activation of Sterol Regulatory Element-Binding Proteins. (査読付)
    J. Med. Chem., 54(13), 4923-4927 (2011)
  33. Kuramochi, K., Fukudome, K., Kuriyama, I., Takeuchi, T., Sato, T., Kamisuki, S., Tsubaki, K., Sugawara, F., Yoshida, H., Mizushina, Y.
    Synthesis and structure-activity relationships of dehydroaltenusin derivatives as selective DNA polymerase α inhibitors. (査読付)
    Bioorg. Med. Chem., 17(20), 7227-7238 (2009)
  34. Kamisuki, S., Mao, Q., Abu-Elheiga, L., Gu, Z., Kugimiya, A., Kwon, Y., Shinohara, T, Kawazoe Y., Sato, S., Asakura, K., Choo, H. P., Sakai, J., Wakil, S. J., Uesugi, M.
    A small molecule that blocks fat synthesis by inhibiting the activation of SREBP. (査読付)
    Chem. Biol., 16(8), 882-892 (2009)
  35. Narukawa M., Kanbara, K., Tominaga, Y., Aitani, K., Fukuda, K., Kodama, T., Murayama, N., Nara, Y., Arai, T., Konno, M., Kamisuki, S., Sugawara, F., Iwai, M., Inoue, Y.
    Chlorogenic acid facilitates root hair formation in lettuce seedlings. (査読付)
    Plant Cell Physiol., 50(3), 504-514 (2009)
  36. Jung, D., Shimogawa, H., Kwon, Y., Mao, Q., Sato, S., Kamisuki, S., Kigoshi, H., Uesugi, M.
    Wrenchnolol derivative optimized for gene activation in cells. (査読付)
    J. Am. Chem. Soc., 131(13), 4774-4782 (2009)
  37. Kuriyama, I., Fukudome, K., Kamisuki, S., Kuramochi, K., Tsubaki, K., Sakaguchi, K., Sugawara, F., Yoshida, H., Mizushina, Y.
    The specific inhibitory effect of demethoxydehydroaltenusin, a derivative of dehydroaltenusin, on mammalian DNA polymerase α.(査読付)
    Int. J. Mol. Med., 22(6), 793-799 (2008)
  38. Kuramochi, K., Aoki, T., Nakazaki, A., Kamisuki, S., Takeno, M., Ohnishi, K., Kimoto, K., Watanabe, N., Kamakura, T., Arai, T., Sugawara, F., Kobayashi, S.
    Synthesis of neoechinulin A and derivatives. (査読付)
    Synthesis, 23, 3810-3818 (2008)
  39. Nishida, M., Ida, N., Horio, M., Takeuchi, T., Kamisuki, S., Murata, H., Kuramochi, K., Sugawara, F., Yoshida, H., Mizushina, Y.
    Hymenoic acid, a novel specific inhibitor of human DNA polymerase lambda from a fungus of Hymenochaetaceae sp. (査読付)
    Bioorg. Med. Chem., 16(9), 5115-5122 (2008)
  40. Kimoto, K., Aoki, T., Shibata, Y.,Kamisuki, S., Sugawara, F., Kuramochi, K., Nakazaki, A., Kobayashi, S., Kuroiwa, K., Watanabe, N., Arai, T.
    Structure-activity relationships of neoechinulin A analogues with cytoprotection against peroxynitrite-induced PC12 cell death. (査読付)
    J. Antibiot., 60(10), 614-621 (2007)
  41. An approach to evaluate two-electron reduction of 9,10-phenanthraquinone and redox activity of the hydroquinone associated with oxidative stress. (査読付)
    Taguchi, K., Fujii, S., Yamano, S., Cho, A.K., Kamisuki, S., Nakai, Y., Sugawara, F., Froines, J.R., Kumagai, Y.
    Free Radic. Biol. Med., 43(5), 789-799 (2007)
  42. Kamisuki, S., Ishimaru, C., Onoda, K., Kuriyama, I., Ida, N., Sugawara, F., Yoshida, H., Mizushina, Y.
    Nodulisporol and Nodulisporone, novel specific inhibitors of human DNA polymerase lambda from a fungus, Nodulisporium sp. (査読付)
    Bioorg. Med. Chem., 15(9), 3109-3114 (2007)
  43. Sato, S., Kwon, Y., Kamisuki, S., Srivastava, N., Mao, Q., Kawazoe, Y., Uesugi, M.
    Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. (査読付)
    J. Am. Chem. Soc. 129(4), 873-80 (2007)
  44. Maeda, N., Kokai, Y., Ohtani, S., Sahara, H., Kuriyama, I., Kamisuki, S., Takahashi, S., Sakaguchi, K., Sugawara, F., Yoshida, H., Sato, N., Mizushina, Y.
    Anti-tumor effects of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase alpha. (査読付)
    Biochem. Biophys. Res. Commun., 352(2), 390-396 (2007)
  45. Aoki, T., Kamisuki, S., Kimoto, M., Ohnishi, K., Takakusagi, Y., Kuramochi, K., Takeda, Y., Nakazaki, A., Kuroiwa, K., Ohuchi, T., Sugawara, F., Arai, T., Kobayashi, S.
    Total synthesis of (-)-neoechinulin A. (査読付)
    Synlett, 5, 677-680 (2006)
  46. Murakami, S., Kamisuki, S., Takata, K., Kasai, N., Kimura, S., Mizushina, Y., Ohta, K., Sugawara, F., Sakaguchi, K.
    Site-directed mutational analysis of structural interactions of low molecule compounds binding to the N-terminal 8 kDa domain of DNA polymerase beta. (査読付)
    Biochem. Biophys. Res. Commun., 350(1), 7-16 (2006)
  47. Uchiyama, Y., Tagami, J., Kamisuki, S., Kasai, N., Oshige, M., Chiku, H., Ibe, S., Koiwai, O., Sugawara, F., Sakaguchi, K.
    Selective inhibitors of terminal deoxyribonucleotidyltransferase (TdT): baicalin and genistin.
    Biochim. Biophys. Acta., 1725(3), 298-304 (2005)
  48. Kamisuki, S., Takahashi, S., Mizushina, Y., Sakaguchi, K., Nakata, T., Sugawara, F.
    Precise structural elucidation of dehydroaltenusin, a specific inhibitor of mammalian DNA polymerase α.(査読付)
    Bioorg. Med. Chem., 12(20), 5355-5359 (2004)
  49. Murakami-Nakai, C., Maeda, N., Yonezawa, Y, Kuriyama, I., Kamisuki, S., Takahashi, S., Sugawara, F., Yoshida, H., Sakaguchi, K., Mizushina, Y.
    The effects of dehydroaltenusin, a novel mammalian DNA polymerase α inhibitor, on cell proliferation and cell cycle progression. (査読付)
    Biochim. Biophys. Acta, 1674(2), 193-199 (2004)
  50. Kamisuki, S., Takahashi, S., Mizushina, Y., Hanashima, S., Kuramochi, K., Kobayashi, S., Sakaguchi, K., Nakata, T., Sugawara, F.
    Total synthesis of dehydroaltenusin. (査読付)
    Tetrahedron, 60(27), 5695-5700 (2004)
  51. Ogawa, A., Murakami, C., Kamisuki, S., Kuriyama, I., Yoshida, H., Sugawara, F., Mizushina, Y.
    Pseudodeflectusin, a novel isochroman derivative from Aspergillus pseudodeflectus a parasite of the sea weed, Sargassum fusiform, as a selective human cancer cytotoxin. (査読付)
    Bioorg. Med. Chem. Lett., 14(13), 3539-3543 (2004)
  52. Oshige, M., Takenouchi, M., Kato, Y, Kamisuki, S., Takeuchi, T., Kuramochi, K., Shiina, I., Suenaga, Y., Kawakita, Y., Kuroda, K., Sato, N., Kobayashi, S., Sugawara, F., Sakaguchi, K.
    Taxol derivatives are selective inhibitors of DNA polymerase α.(査読付)
    Bioorg. Med. Chem., 12(10), 2597-2601 (2004)
  53. Mizushina, Y., Hirota, M., Murakami, C., Ishidoh, T., Kamisuki, S., Shimazaki, N., Takemura, M., Perpelescu, M., Suzuki, M., Yoshida, H., Sugawara, F., Koiwai, O., Sakaguchi, K.
    Some anti-chronic inflammatory compounds are DNA polymerase λ-specific inhibitors. (査読付)
    Biochem. Pharmacol., 66(10), 1935-1944 (2003)
  54. Takahashi, S., Kamisuki, S., Mizushina, Y., Sakaguchi, K., Sugawara, F., Nakata, T.
    Total synthesis of dehydroaltenusin. (査読付)
    Tetrahedron Lett., 44(9), 1875-1877 (2003)
  55. Mizushina, Y., Ishidoh, T., Kamisuki, S., Nakazawa, S., Takemura, M., Sugawara, F., Yoshida, H., Sakaguchi, K.
    Flavonoid glycoside: a new inhibitor of eukaryotic DNA polymerase α and a new carrier for inhibitor-affinity chromatography. (査読付)
    Biochem. Biophys. Res. Commun., 301(2), 480-487 (2003)
  56. Murakami, C., Kumagai, T., Hada, T., Kanekazu, U., Nakazawa, S., Kamisuki, S., Maeda, N., Xu, X., Yoshida, H., Sugawara, F., Sakaguchi, K., Mizushina, Y.
    Effects of glycolipids from spinach on mammalian DNA polymerases. (査読付)
    Biochem. Pharmacol., 65(2), 259-267 (2003)
  57. Mizushina, Y., Kamisuki, S., Kasai, N., Ishidoh, T., Shimazaki, N., Takemura, M., Asahara, H., Linn, S., Yoshida, S., Koiwai, O., Sugawara, F., Yoshida, H., Sakaguchi, K.
    Petasiphenol: a DNA polymerase λ inhibitor. (査読付)
    Biochemistry, 41(49), 14463-14471 (2002)
  58. Murakami, C., Takemura, M., Sugiyama, Y., Kamisuki, S., Asahara, H., Kawasaki, M., Ishidoh, T., Linn, S., Yoshida, S., Sugawara, F., Yoshida, H., Sakaguchi, K., Mizushina, Y.
    Vitamin A-related compounds, all-trans retinal and retinoic acids, selectively inhibit activities of mammalian replicative DNA polymerases. (査読付)
    Biochim. Biophys. Acta, 1574(1), 85-92 (2002)
  59. Kamisuki, S., Murakami, C., Ohta, K., Yoshida, H., Sugawara, F., Sakaguchi, K., Mizushina, Y.
    Actions of derivatives of dehydroaltenusin, a new mammalian DNA polymerase α-specific inhibitor. (査読付)
    Biochem. Pharmacol., 63(3), 421-427 (2002)
  60. Mizushina, Y., Kamisuki, S., Kasai, N., Shimazaki, N., Takemura, M., Asahara, H., Linn, S., Yoshida, S., Matsukage, A., Koiwai, O., Sugawara, F., Yoshida, H., Sakaguchi, K.
    A plant phytotoxin, solanapyrone A, is an inhibitor of DNA polymerase β and λ.(査読付)
    J. Biol. Chem., 277(1), 630-638. (2002)
  61. Mizushina, Y., Sugiyama, Y., Yoshida, H., Hanashima, S., Yamazaki, T., Kamisuki, S., Ohta, K., Takemura, M., Yamaguchi, T., Matsukage, A., Yoshida, S., Saneyoshi, M., Sugawara, F., Sakaguchi, K.
    Galactosyldiacylglycerol, a mammalian DNA polymerase α-specific inhibitor from a sea alga, Petalonia bingbamiae. (査読付)
    Biol. Pharm. Bull., 24(9), 982-987 (2001)
  62. Mizushina, Y., Kamisuki, S., Mizuno, T., Takemura, M., Asahara, H., Linn, S., Yamaguchi, T., Matsukage, A., Hanaoka, F., Yoshida, S., Saneyoshi, M., Sugawara, F., Sakaguchi, K.
    Dehydroaltenusin, a mammalian DNA polymerase α inhibitor. (査読付)
    J. Biol. Chem., 275(43), 33957-33961 (2000).

解説・総説

  1. 紙透伸治
    コンゲンシンAが阻害する制御されたネクローシス
    ファルマシア, 52, 1156 (2016)
  2. Kuramochi, K., Kuriyama, I., Mori, M., Kamisuki, S., Takahashi, S., Tsubaki, K., Sugawara, F., Sakaguchi, K., Yoshida, H., Mizushina, Y.
    Syntheses of dehydroaltenusin, a selective inhibitor of mammalian DNA polymerase α. (査読付)
    Current Organic Synthesis, 8, 134-144 (2011)
  3. 紙透伸治、上杉志成
    Discovering high-affinity ligands for proteins: SAR by NMR
    蛋白質核酸酵素, 52, 1818-1819 (2007)
  4. 紙透伸治、上杉志成
    小分子化合物で転写因子をつくる
    化学と生物, 45, 232-234 (2007)
  5. Maeda, N., Kamisuki, S., Takahashi, S., Yoshida, H., Sakaguchi, K., Sugawara, F., Mizushina, Y.
    The in vitro and in vivo inhibitory effect of dehydroaltenusin: a specific inhibitor of mammalian DNA polymerase α(査読付)
    Current Bioactive Compounds, 2, 3-11 (2006)

知的所有権

  1. 発明の名称:牛白血病ウイルスに対する薬剤スクリーニング法
    出願番号:特願2019- 54771 
    出願日:2019年3月22日
    発明者:村上裕信、紙透伸治
  2. Title:Compositions and methods for the treatment of metabolic disorders
    Application No. US 15/061961.
    Application Date: Mar 4, 2016
    Inventors: Uesugi, M., Wakil, S.J., Abu-Elheiga, L., Mao, Q., Kamisuki, S., Kugimiya, A., Watanabe, M.

  3. 発明の名称:中枢神経細胞保護剤、及び中枢神経変性疾患の予防又は治療剤
    出願番号:特願2015-096689 
    出願日:2015年5月11日
    発明者:篠田陽、紙透伸治、古市貞一、菅原二三男、今堀龍志

  4. 発明の名称:アデニン誘導体又はその薬理学的に許容しうる塩、その製造方法、及びその用途
    出願番号:特願2014-024257
    出願日:2014年2月12日
    発明者:菅原二三男、竹内倫文、紙透伸治、大類洋、鈴木康夫

  5. 発明の名称:抗癌活性を有する化合物
    出願番号:特願2013-061159
    出願日:2013年3月23日
    発明者:水品善之、吉田弘美、栗山磯子、菅原二三男、紙透伸治
  6. 発明の名称:DNAポリメラーゼ阻害活性を有する新規化合物
    出願番号:特願2012-066614
    出願日:2012年3月23日
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  7. 発明の名称:DNAポリメラーゼ阻害活性を有する新規化合物
    出願番号:特願2012-066630
    出願日:2012年3月23日
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  8. 発明の名称:DNAポリメラーゼ阻害活性を有する新規化合物
    出願番号:特願2012-066635
    出願日:2012年3月23日
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  9. 発明の名称:DNAポリメラーゼ阻害活性を有する新規化合物
    出願番号:特願2012-066727
    出願日:2012年3月23日
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  10. 発明の名称:DNAポリメラーゼ阻害活性を有する新規化合物
    出願番号:特願2012-066745
    出願日:2012年3月23日
    出願人:学校法人神戸学院
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  11. 発明の名称:DNAポリメラーゼ阻害活性を有する新規化合物
    出願番号:特願2012-066777
    出願日:2012年3月23日
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  12. 発明の名称:DNAポリメラーゼ阻害活性を有する化合物
    出願番号:特願2012-066815
    出願日:2012年3月23日
    出願人:学校法人神戸学院
    発明者:水品善之、竹内倫文、紙透伸治、栗山磯子、菅原二三男、吉田弘美
  13. Title: Compositions and Methods for the Treatment of Metabolic Disorders
    Patent no. WO 2008097835 Application no. WO 2008-US52778
    Inventors: Uesugi, M, Wakil, S. J., Abu-Elheiga, L., Mao, Q., Kamisuki, S., Kugimiya, A.

研究助成

伊藤記念財団 研究助成
研究課題:天然化合物による牛白血病ウイルス感染制御を目指した基礎的研究
期間:令和元年度

日本農芸化学会 研究奨励金
研究課題:ピレノシンA の抗腫瘍効果の検証及び作用点の解明
期間:令和元年度

科学研究費補助金 基盤研究C(研究代表者)
申請課題:小分子化合物を用いた活性窒素による神経細胞傷害機構の解明
期間:平成30年度~令和2年度

日本医療研究開発機構(AMED) 肝炎等克服実用化研究事業 (研究分担者)
研究開発課題:核内ホルモン受容体リガンドを利用した難治性C型肝炎および脂肪性肝炎制御戦略の構築(研究代表者:渡士幸一)
期間:平成30年度~令和2年度

麻布大学 私立大学ブランディング事業
プロジェクトタイトル:Chemical geneticsによるウイルス感染症の病態原因遺伝子の同定 (研究代表者)
期間:平成29年度~令和元年度

科学研究費補助金 基盤研究C(研究代表者)
申請課題:ネオエキヌリンA の標的分子の同定と作用機構解明
期間:平成27年度~平成29年度

科学研究費補助金 基盤研究C(研究分担者)
申請課題:抗ウイルス抗体を産生する新規抗ウイルス剤EdAP の研究 (研究代表者:菅原二三男)
期間:平成27年度~平成29年度

科学研究費補助金 若手研究B(研究代表者)
申請課題:単極紡錘体を誘導する小分子の作用機構解析
期間:平成25年度~平成26年度

科学研究費補助金 若手研究B(研究代表者)
申請課題:フッ素を利用した光親和性プローブの開発と応用
期間:平成22年度~平成24年度

科学研究費補助金 特別研究員奨励費(研究代表者)
申請課題:小分子転写因子の開発と応用
期間:平成18年度~平成20年度

科学研究費補助金 特別研究員奨励費(研究代表者)
申請課題:DNAポリメラーゼ阻害物質の化学的研究とその作用機構の解明
期間:平成15年度~平成16年度

所属学会

日本農芸化学会
日本ケミカルバイオロジー学会
日本薬学会
アメリカ化学会
日本獣医学会



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