生化学研究室

1. Depletion of Gangliosides Enhances Articular Cartilage Repair in Mice. Matsuoka M, Onodera T, Homan K, Sasazawa F, Furukawa J, Momma D, Baba R, Hontani K, Joutoku Z, Matsubara S, Yamashita T, Iwasaki N. Scientific Reports. 2017; 7, Article number: 43729
2. Lipophilic triphenylphosphonium derivatives enhance radiation- induced cell killing via inhibition of mitochondrial energy metabolism in tumor cells. Yasui H, Yamamoto K, Suzuki M, Sakai Y, Bo T, Nagane M, Nishimura E, Yamamori T Yamasaki T, Yamada K, Inanami O. Cancer Letters. 2017; 390, 160e167
3. Lethality of mice bearing a knockout of the Ngly1-gene is partially rescued by the additional deletion of the Engase gene. Fujihira H, Masahara-Negishi Y, Tamura M, Huang C, Harada Y, Wakana S, Takakura D, Kawasaki N, Taniguchi N, Kondoh G, Yamashita T, Funakoshi Y, Suzuki T. PLoS Genetics. 2017; Apr 20;13(4):e1006696

2016

1. Anticancer potential of diarylidenyl piperidone derivatives, HO-4200 and H-4318, in cisplatin resistant primary ovarian cancer. ElNaggar AC, Saini U, Naidu S, Wanner R, Sudhakar M, Fowler J, Nagane M, Kuppusamy P, Cohn DE, and Selvendiran K. Cancer Biology & Therapy. 2016; 17(10): 1107-1105.
2. Evaluation of the relative biological effectiveness of spot-scanning proton irradiation in vitro.Maeda K, Yasui H, Matsuura T, Yamamori T, Suzuki M, Nagane M, Nam JM, Inanami O, Shirato H. Jounal of Radiation Research. 2016; 57(3): 307-11.
3. Skeletal Muscle Oxygenation Measured by EPR Oximetry Using a Highly Sensitive Polymer-Encapsulated Paramagnetic Sensor. Hou H, Khan N, Nagane M, Gohain S, Chen EY, Jarvis LA, Schaner PE, Williams BB, Flood AB, Swartz HM, and Kuppusamy P. Advances in Experimental Medicine and Biology. 2016; 923: 351-357.

2015

1. Activation of eNOS in endothelial cells exposed to ionizing radiation involves components of the DNA damage response pathway. Nagane M, Yasui H, Sakai Y, Yamamori T, Niwa K, Hattori Y, Kondo T, and Inanami O. Biochemical and Biophysical Research Communications. 2015; 456: 541-546
2. Inhibition of the mitochondrial fission protein dynamin-related protein 1 (Drp1) impairs mitochondrial fission and mitotic catastrophe after X-irradiationYamamori T, Ike S, Bo T, Sasagawa T, Sakai Y, Suzuki M, Yamamoto Y, Nagane M, Yasui H, and Inanami O. Molecular Biology of The Cell. 2015; 25: 4607-4617
3. ErbB2 over-expression up-regulatdes anti-oxidant enzymes, reduces basal levels of reactive oxygen species and protects against doxorubicin cardiotoxicity. Gabrielson K, Belmonte F, Das S, Sysa-Shah P, Sivakumaran V, Stanley B, Guo X, Paolocci N, Aon M, Nagane M, Kuppusamy P, and Steenbergen C. AJP-Heart and Circulatory Physiology. 2015; 309: H1271-H1280
4. Ohanyan V, Yin L, Bardakjian R, Kolz C, Enrick M, Hakobyan T, Kemetz J, Bratz I, Luli J, Nagane M, Hou H, Kuppusamy P, Graham J, Kwan FF, Janota D, Oyewumi MO, Logan S, Lindner JR, and Chilian WM. Requisite Role of Kv1.5 Channels in Coronary Metabolic Dilation. Circulation Research. 2015; 117(7): 612-621.

2014

1. Inhibition of GM3 synthase attenuates neuropathology of niemann-pick disease type C by affecting sphingolipid metabolism. Molecules and Cells. Lee H, Lee JK., Bae YC, Yang SH, Okino N, Schuchman EH, Yamashita T, Bae JS, and Jin HK. 2014; 37(2):161-171.
2. Sasazawa F, Onodera T, Yamashita T., Seito N, Tsukuda Y, Fujitani N, Shinohara Y, Iwasaki N. Depletion of gangliosides enhances cartilage degradation in mice. Osteoarthritis Cartilage. 2014; 22(2): 313-322.

2013

1. Activin receptor-like kinase5 inhibition suppresses mouse melanoma by ubiquitin degradation of Smad4, thereby derepressing eomesodermin in cytotoxic T lymphocytes. Yoon JH, Jung SM, Park SH, Kato M, Yamashita T, Lee IK, Sudo K, Nakae S, Han JS, Kim OH, Oh BC, Sumida T, Kuroda M, Ju JH, Jung KC, Park SH, Kim DK, Mamura M. EMBO Molecular Medicine. 2013; 5(11): 1720-1739.
2. Improvement of spontaneous alternation behavior deficit by activation of α4β2 nicotinic acetylcholine receptor signaling in the ganglioside GM3-deficient mice.Niimi K, Nishioka C, Miyamoto T, Takahashi E. Miyoshi I, Itakura C, and Yamashita T. Biomedical Reseach. 2013; 34(4):189-195.
3. Effect of ganglioside GM3 synthase gene knockout on the glycoprotein N-glycan profile of mouse embryonic fibroblast. Nagahori N, Yamashita T, Amano M, and Nishimura S. ChemBioChem. 2013; 14(1):73-82.

総説

2017